Pre - emptive immunotherapy with CD 8 - depleted donor lymphocytes after CD 34 - selected allogeneic peripheral blood stem cell
نویسنده
چکیده
Design and Methods. Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60, donors donated lymphocytes that were CD8-depleted and separated into 3 aliquots containing 2×106, 1×107 and 5×107 CD3+ cells/kg (patients 1-13) or into 2 aliquots containing 1×107 and 5×107 CD3+ cells/kg (patients 14-24). The 1st aliquot was infused on day 60 and the other 1 (2) cryopreserved and infused on days 100 (and 140).
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تاریخ انتشار 2002